I this article, Darius Rucker said he has received 5000 rejection letters in his life (estimate, of course).  "No" just means, go ask someone else.

Life is good!
Olga Solovei
Life is good!

I couldn't even venture a guess as to how many people have told me "no, no you aren't capable, good enough, have the skills, will ever be able to do that.  Even now, people I work with people who question me on ridiculous things.  Even when my resume reads like a novel and theirs is a sticky note.  Most of that is due to prejudice.  Me being "different".

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